20世纪八十年代以来，风险社会、治理以及模式2的知识生产等理论都对科学与社会边界的模糊以及二者间协同进化的关系进行了讨论。以生物技术为例，实验室中“可靠”的知识已经无法满足社会的需要，一种新型的社会鲁棒性的知识必须在科学与社会共同在场的公共空间内通过磋商完成。然而一系列失败的案例表明，由于不同群体之间的隔阂，这种磋商难以在公共空间内自然达成。STS（Sciene and Technology Studies）视科学技术为一种社会现象，是一个以建构主义科学观为核心理念的跨学科研究领域。在新兴科技领域中，STS研究者的身份由一种外在于科学的观察者，逐渐演变为内在于科学的参与者，这种研究范式的沿革被称为STS参与进路的转向。通过对英国经济与社会研究理事会（ESRC）资助的基因组学网络（Genomics Network）的案例研究，本文对STS参与进路的形成过程以及其发挥作用的方式进行了考察。自上世纪九十年代以来，英国的公众风险意识的形成以及政府科技政策范式的演变都为参与进路的实现埋下了伏笔；参与进路从对已有社会科学研究纲领的批判中获得了动力；英国基因组学网络的建制化为参与进路得以实施提供了制度空间；在新兴的合成生物学等领域中，科技投入体制以及科学家共同“邀请”STS研究者参与到新兴生物技术知识的生产中——参与进路得以实现。公共空间中的STS研究者能够作为跨越科学与社会边界的行动者，促成不同群体间的磋商与协调，以促进社会鲁棒性知识生产的完成。最后，本文对STS的参与进路进行反思。参与进路是对STS理论“建构主义传统”与“行动主义传统”两股张力的融合；完成了建构主义科学观在更高的层面的介入性实践。同时，参与进路的形成反映了科学观以及科学与社会关系的根本变革。在新的社会—科学空间中，界定“科学”的依据不再只是“自然的”现实，还包括塑造科学、同时也被科学塑造着的社会现实。

From the 1980s, the theories as risk society, governance and the mode-2 knowledge production began to investigate the blurred boundary between science and the society and their co-evolution. Such as in area of biotechnology, the ‘reliable’ knowledge produced from the laboratory could hardly satisfy the need of the society, which open a door to a social-robust knowledge. The social-robust knowledge shall produce in a public space which includes the presentation from both the science and the society through negociation. But a series of failing cases indicate that because of the boundaries between different stakeholders, the negociation is difficult to achieve spontaneous in the public space.STS(Science and Technology Studies), which considers science and technology as a social phenomenon, is a research area (not discipline) sharing a constructivism view of science. In the emerging technology, STSer’s role has been changed from an observer outside the science into an actor, who’s within the expanded boundary of science, which is presumed as the participatory turn of the paradigm of STS theoretic evolution. Through the case study of the ESRC Genomics Network, the author carefully explored the shaping of the STS participatory approach and how it developed its role. Form the 1990s, the risk perception of the public and the shift of the policy paradigm form government to governance in the UK provided a incentive of the participatory approach, also the new approach has gained a driving force from the critique of of the old agenda. The institution of the ESRC Genomics Network provided a embeddedness to the approach. In the emerging area of synthetic biology, the re-invented research investment system and the ‘invitation’ from the science community has brought the STSers into the public space and been involved in the production of scientific knowledge, which indicates the reliazation of the STS participatory approach. Under this approach, the researchers accrossed the boundary between science and society which helped the mediation and negociation between scienctists, public and the policy makers, which may accomplish the production the social robust knowledge. In the debating of participatory approach, the thesis deems the participatory approach is the fusion of the tesion between ‘constructivism’ and the ‘activism’, which has accomplished the intervened practice of the constructivism in a upper level. Meanwhile, the participatory approach reflects the new perspective of science fundamentally. In the society-science sphere, not only the ‘natural’ reality defines ‘science’, but also the social reality which shapes and being shaped by science.